Homing Sweet Homing: Odyssey of Hematopoietic Stem Cells
نویسندگان
چکیده
منابع مشابه
Advances and challenges in storage, transplantation, expansion and homing of Umbilical Cord Blood Hematopoietic Stem Cells (UCB-HSCs)
Abstract Background and Objectives Umbilical cord blood hematopoietic stem cells (UCB-HSCs) have high potential capabilities in the treatment of hematological and non-hematological disorders. Awareness of biology, self-renewal, homing, expansion, storage, and transplantation can lead to optimal use of these cells. Materials and Methods In this Review article in order to investigate the adv...
متن کاملMolecular Mechanisms Underlying Bone Marrow Homing of Hematopoietic Stem Cells
The formation of blood cells, also called hematopoiesis, is a complex process that occurs in the bone marrow and depends on correct regulation of hematopoietic cell fate decisions. Aberrant regulation of hematopoiesis can result in the development of severe malignant and non-malignant hematological disorders, including leukemia. Hematopoietic stem cell transplantation is the most powerful treat...
متن کاملImpaired functionality and homing of Fancg-deficient hematopoietic stem cells.
Fanconi anemia (FA) is a human rare genetic disorder characterized by congenital defects, bone marrow (BM) failure and predisposition to leukemia. The progressive aplastic anemia suggests a defect in the ability of hematopoietic stem cells (HSC) to sustain hematopoieis. We have examined the role of the nuclear FA core complex gene Fancg in the functionality of HSC. In Fancg-/- mice, we observed...
متن کاملStrategies to Improve Homing of Stem Cells to achieve better Efficacy in Stem Cell Therapy
Stem/progenitor cell based therapeutic approach in our daily routine clinical practice, has been elusive dream in medical sciences and improvement of stem cell homing as one of major challenges in cell therapy programs, has been considered a promising milestone. It has been proved that stem/progenitor cells exhibit a homing response to injured tissues/organs, mediated by interactions of chemoki...
متن کاملAn in vitro model of hematopoietic stem cell homing demonstrates rapid homing and maintenance of engraftable stem cells.
Hematopoietic stem cell (HSC) homing is believed to rely heavily on adhesion interactions between stem cells and stroma. An in vitro assay was developed for adhesion of engraftable HSCs in bone marrow suspensions to pre-established Dexter-type long-term bone marrow culture stromal layers. The cell numbers in the adherent layer and supernatant were examined, along with the engraftment capability...
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ژورنال
عنوان ژورنال: Immunity
سال: 2006
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2006.11.006